NEW YORK —April 1, 2024 —Actinium Pharmaceuticals, Inc. , a trailblazer in the development of Antibody Radiation Conjugates (ARCs) and targeted radiotherapy treatments, is at the forefront of oncology innovation with its latest venture into improving CAR T-cell therapy. The company announced a partnership with the University of Texas Southwestern Medical Center (UT Southwestern) to initiate a clinical trial focused on their pioneering product, Iomab-ACT, as a conditioning agent before CAR T-cell therapy. This move not only underscores Actinium’s commitment to enhancing cancer treatment but also marks a significant stride towards reducing the toxicities associated with current conditioning regimens.
Iomab-ACT: A Leap Forward
Iomab-ACT is designed to replace the chemotherapy conditioning regimens that are presently used before cell and gene therapies. These traditional regimens are known for their significant toxicities, such as immune effector cell-associated neurotoxicity syndrome (ICANS) and cytokine release syndrome (CRS), which can limit patient access to CAR-T therapies and result in poorer outcomes. Iomab-ACT aims to provide targeted lymphodepletion with minimal incidences of these major toxicities, potentially increasing patient access to CAR-T therapies and improving their efficacy.
A Pivotal Moment for Actinium
Sandesh Seth, Actinium’s Chairman and CEO, highlights the importance of the Iomab-ACT program, viewing it as a potential game-changer in the practice of cellular therapies. With the CAR-T and gene therapy market expected to nearly double by 2030, reaching approximately 93,000 patients annually in the U.S. alone, Iomab-ACT positions Actinium at the cutting edge of targeted radiotherapy applications.
Collaborative Clinical Trials
Dr. Avinash Desai, Actinium’s Chief Medical Officer, expresses excitement over the collaboration with UT Southwestern for this groundbreaking trial. The study aims to demonstrate Iomab-ACT’s ability to reduce CAR-T related toxicities, such as ICANS and CRS, and to improve overall therapy efficacy. Preliminary results from a phase 1 trial with Memorial Sloan Kettering’s CD19 CAR-T therapy have shown promising outcomes, laying the groundwork for the upcoming study with a commercial CAR-T therapy.
The Future of Cellular Therapy Conditioning
The development of Iomab-ACT is part of Actinium’s broader vision to revolutionize conditioning for cellular and gene therapies. With a rapidly expanding pipeline of CAR-T and gene therapies, the potential patient population for these treatments is expected to grow significantly. Actinium’s continued development of targeted conditioning programs like Iomab-ACT holds the promise of enhancing access and outcomes for patients undergoing these transformative treatments.
Actinium Pharmaceuticals: A Visionary in Oncology
Actinium Pharmaceuticals stands as a leader in developing targeted radiotherapies aimed at improving survival for patients who have exhausted conventional oncology treatments. With advanced pipeline candidates like Iomab-B and Actimab-A showing potential in extending survival outcomes for acute myeloid leukemia, Actinium is poised to make significant contributions to the field of oncology.
For traders and investors, Actinium’s innovative approach to CAR T-cell therapy conditioning represents a compelling investment opportunity. The company’s focus on improving the efficacy and accessibility of CAR-T and gene therapies could position it as a key player in the rapidly growing oncology market. As Actinium continues to advance its pipeline and forge strategic partnerships, its potential for growth and impact in the biopharmaceutical industry remains significant.
Significant Upside Potential
Based on 4 Wall Street analysts offering 12 month price targets for Actinium Pharmaceuticals in the last 3 months. The average price target is $30.50 with a high forecast of $50.00 and a low forecast of $16.00. The average price target represents a 289.53% change from the last price of $7.83.
Stay tuned for updates on this exciting journey, as Actinium Pharmaceuticals continues to redefine the landscape of cancer treatment and cellular therapy.
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Sources:
https://www.tipranks.com/stocks/atnm/forecast#google_vignette
https://finance.yahoo.com/news/actinium-announces-clinical-trial-study-111800504.html
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